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KMID : 0984720070390030165
Infection and Chemotherapy
2007 Volume.39 No. 3 p.165 ~ p.167
Trend of Resisrance to the Third Generation Cephalosporin of Gram Negative Bacteria in Patients with Spontaneous Bacterial Peritonitis
Bang Ji-Hwan

Park Joo-Kyung
Lee Hyo-Suk
Song Kyoung-Ho
Park Wan-Beom
Kim Sung-Han
Kim Hong-Bin
Kim Nam-Joong
Oh Myoung-Don
Choe Kang-Won
Kim Eui-Chong
Abstract
The third generation cephalosporin is widely used in treatment of spontaneous bacterial peritonitis (SBP). Resistance to the third generation cephalosporin was associated with poor outcome in patients with SBP. Thus it is necessary to know the changes in resistance rate. We planned to investigate retrospectively on resistance rate of the third generation cephalosporin of gram negative bacteria isolated in patients with SBP, who visited Seoul National University Hospital between 1998 and 2006. The Clinical and Laboratory Standards Institute guidelines were applied for antibiotic susceptibility test. A total of 269 consecutive episodes of clinically and microbiologically proven SBP was identified during the study period and 209 cases were caused by gram negative organisms. Among 209 isolates, 22 (10.5%) showed resistance to the third generation cephalosporin. The prevalence of resistance was decreasing during the study period (P=0.014).
KEYWORD
Cephalosoprin resistance, peritonitis, Liver cirrhosis
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